ANTIOXIDANT PROPERTY AND INHIBITION OF ERECTILE DYSFUNCTIONLINKED ENZYMES BY SOME COLA SPP AND GACINIA KOLA a* b a

• A. O. Ademiluyi

  a Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria Department of Biomedical Technology, Federal University of Technology, Akure, Ondo-State, Nigeria b

  Author

• S. I. Oyeleye

  a Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria Department of Biomedical Technology, Federal University of Technology, Akure, Ondo-State, Nigeria b

  Author

• G. Oboh

  a Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria Department of Biomedical Technology, Federal University of Technology, Akure, Ondo-State, Nigeria b

  Author

Erectile dysfunction (ED) is a common problem among men. Kola nut seeds are claimed to possess aphrodisiac effects and have been employed in folklore for the management of ED. This study investigated the possible mechanism of actions behind the aphrodisiac properties of some tropical Cola spp [Cola nitida (white and red) and Cola acuminata] and, Garcinia kola via their antioxidant properties and possible inhibition of some key enzymes (AChE, ACE and Arginase) linked to ED in vitro. The aqueous extract was prepared and the radicals (DPPH* and ABTS*) scavenging and Fe2+ chelating abilities, ferric reducing antioxidant power (FRAP) as well as the effects on the Fe-induced lipid peroxidation in rats' penile homogenate were determined. The total phenolic (phenol and flavonoids) contents were also determined. The extracts scavenged the radicals, chelated Fe2+, and inhibited Fe2+lipid peroxidation in a dose-dependent pattern. The results revealed that Cola acuminata had the higher arginase and AChE inhibitory activities than Garcinia kola while the later had the highest ACE inhibitory effect. Interestingly, Cola acuminata had the highest phenolic content among the entire Cola sample tested. These antioxidative and enzyme inhibitory effects of the selected kola nut seeds may be due to their phenolic contents and these could also be some possible mechanisms underlying their erectogenic potential in folklore medicines.

1. A. O. Ademiluyi, a Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria Department of Biomedical Technology, Federal University of Technology, Akure, Ondo-State, Nigeria b

   a Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria Department of Biomedical Technology, Federal University of Technology, Akure, Ondo-State, Nigeria b

2. S. I. Oyeleye, a Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria Department of Biomedical Technology, Federal University of Technology, Akure, Ondo-State, Nigeria b

   a Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria Department of Biomedical Technology, Federal University of Technology, Akure, Ondo-State, Nigeria b

3. G. Oboh, a Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria Department of Biomedical Technology, Federal University of Technology, Akure, Ondo-State, Nigeria b

   a Department of Biochemistry, Federal University of Technology, Akure, Ondo-State, Nigeria Department of Biomedical Technology, Federal University of Technology, Akure, Ondo-State, Nigeria b

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